Yes – one-way car rental in the USA is possible. If you want to drive coast to coast from Chicago to LA, or between any other cities, just choose a different drop-off location. Be aware that many car rental companies charge a One Way Fee, also known as a drop charge, for this type of rental.
When you search for a one-way rental in the USA on Rentalcars.com, we tell you (before you book) if a car rental company would charge a One Way Fee. And because we deal with so many car rental companies in the USA, you can easily compare them to find the ones with the smallest fees, or even no One Way Fee at all.