The airport is on the A453, very close to the M1 (Junction 23a or 24).
From the airport, you can also take the A42 towards Birmingham or the A50 towards Stoke-on-Trent.
The roads around the airport are generally well-signposted, but you may wish to request a GPS if you are unfamiliar with the area.
The postcode for the airport is DE74 2SA.
Many of the car hire companies have their pick-up counter in the terminal itself, giving you the simplest possible start to your trip.
Book your car hire when you search to guarantee both the price and the car you want.